Forefront of research

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A Novel Sanitizing Technology Invented At The School Of Pharmacy Has Generated A Range Of Products Now In Use In South America

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Prof. Touitou has developed a novel broad spectrum anti-viral and anti-microbial sanitizing technology based on a new concept of action. The mode of action is based on a synergistic combination of ingredients providing high antiviral and antimicrobial activities, yet being non-irritating, quick drying, non-sticky and not drying the skin.  

It prevents the spread of disease by effectively disinfecting hands and surfaces against bacteria, enveloped and non-enveloped viruses. The antimicrobial and antiviral spectrum of the active ingredients include biocidal performance against gram-positive bacteria, gram-negative bacteria, mycobacteria, fungi, enveloped viruses and non-enveloped viruses.

The novel compositions, tested in leading in FDA and EPA certified GLP labs, exhibited effective anti-viral, anti-microbial and/or anti-fungal activity.

Prof. Elka Touitou Head of Innovative Dermal Transdermal &Transmucosal Delivery Group, Institute of Drug Research School of Pharmacy, Faculty of Medicine The Hebrew University of Jerusalem

 

The figures above depict the synergistic antiviral activity of formulations tested for their antiviral activity against Vaccinia virus after 30 & 60 seconds exposure respectively as compared to conventional formulations  

The active ingredients in the products of the novel technology are regarded as safe (GRAS) by the US FDA and are listed in the FDA's EAFUS database. The compositions of the invention can be used in mouthwashes, oral care, hand sanitizing and food Surfaces sanitizers. They can also be used for sanitizing and/or disinfecting surfaces. The new sanitizers are pleasant and non–tacky on the skin.

The IP has been licensed and a range of products are now in use in South America

 

 

The new products answer the unmet medical needs by providing innovative and highly effective sanitizing solution to prevent the spread of bacteria and viruses.

 

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Is Cannabis the Antibiotics of the 21st Century?

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Prof. Doron Steinberg, a researcher and lecturer from the Faculty of Dental Medicine and the Director of the Biofilm Research Lab, says that modern microbiology is not designed to kill viruses but rather to attack the biofilm construction.  In his lab, basic research is combined with clinical applications for a variety of developments and innovations to help combat biofilm as a major cause for infectious diseases like fungal diseases and Cystic Fibrosis that he is currently researching. “My goal is to think of additional applicable applications for cannabinoids, and the possibilities are endless.”

 

Prof. Steinberg says: “We’re involved with a joint study with the head of the Pulmonary Department at Hadassah Ein Kerem, Prof. Malena Cohen.  Cystic Fibrosis is a terminal illness of the biofilm of the lungs with a very rapid morbidity.  Patients are subjected to high levels of all sorts of antibiotics daily which on occasion can be the actual cause of their deaths.  Our hope is to find a cannabinoid that is more effective for the treatment of this condition.”

 

An additional research focus in the joint study, alongside measuring the effectiveness of the cannabinoids, is how they can be best delivered to the lungs.  The team has developed an innovative solution that has already been tested and shown very positive responses.  Last month the team submitted a research grant to the Cystic Fibrosis Foundation.

 

“The next stage that we are already working on, is on more ‘traditional’ infectious diseases, that will be easier to progress with in terms of regulatory issues because if we are successful when it comes to Cystic Fibrosis that these non-terminal diseases should be simpler in that regard.”


 

 

Prof. Steinberg’s most recent findings on cannabinoids research were published in the journal Scientific Reports.  Hebrew University is home to a Cannabinoids Research Center that is a global leader in this field and enjoys working partnerships with leading Israeli companies that are investing in new developments in this area as well as via the “Maadan” track of the Ministry of Health that has a vested interest in developing Israeli interests in science and healthcare.

 

For media publications: 
News1
ישראל היום

 

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Use of gold nano-particles to help drugs penetrate via the skin

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A Discovery That May Change The Very Way We Take Our Medications

As Published on Ynet: Use of gold nano-particles to help drugs penetrate via the skin

 

 

Researchers from Hebrew University said that the discovery offers the potential to help in future drug development and enhance not just treatment of skin diseases but to change the way we all take drugs for all sorts of illnesses.

Researchers have found out how to engineer physical characteristics of nano-particles of gold in order to help them penetrate the skin via hair follicles.  The discovery paves the way for drug companies to develop all sorts of new drugs, not just for skin diseases, but that can be administered quickly and effectively. This is according to a new study that was conducted by a team of researchers led by Prof. Ofra Benny and doctoral student Netanel Friedman from the School of Pharmacy of the Faculty of Medicine at Hebrew University together with doctors from Hadassah Medical Center, Dr. Sharon Merims and Dr. Yonatan Alaya.

 

The researchers explained that nano-particles, miniscule particles that can be viewed only under a very specialized and powerful microscope, are known to provide substantial promise to advance pharmaceutical care, because they improve the chances for the drugs to penetrate to more tissues.  While the ability of these nano-particles to penetrate via the hair follicles was already known, what was less known was which particular nano-particles could best penetrate tissue. 

 

Prof. Ofra Benny, an expert in the field of nano-medicine and pharmaceuticals, utilized a combination of bioengineering with engineered tissues and set out to better understand the physical properties based on size and performance that could best penetrate via the follicles and allowed the best treatment possibilities when reaching the patient’s tissue.

 

 

According to the researchers, the long-term impact of this study can have critical importance for how we get drugs into our bodies.  In the future, drug development through advanced means like nano-technology can allow for benefits that respond directly to specific medical needs.  This will benefit not only diseases that affect the surface of the skin but any disease that is treated by accessing the blood stream.  “We thought about a concept like a nicotine strip, for example.  By introducing an advanced approach of drug delivery via nano-particles, we would be able to receive many drugs via this means.  It’s very simple to affix a sticker or to spread a cream as opposed to oral delivery or injection which is the traditional means in place today,” explains Prof. Benny.

For media publications: YNET

 

 

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ICRS2021 Cannabis Conference: Providing Medical Cannabis to Children with Severe Health Problems - Is It Effective?

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Advertising in the media:

 

1.     Eurekahttps://www.eurekalert.org/pub_releases/2021-06/thuo-uti062021.php

2.     Science Codexhttps://www.sciencecodex.com/understanding-impact-medical-cannabis-kids-meta-analysis-676052

3.     Scientific Inquirer, https://www.jioforme.com/investigate-the-effects-of-medical-cannabis-for-children-science-inquirer/534237/

4.     Jerusalem Post, https://www.jpost.com/health-science/medical-cannabis-may-be-effective-for-young-epilepsy-patients-671674

5.     Media Linehttps://themedialine.org/life-lines/medical-cannabis-may-be-effective-for-young-epilepsy-patients-scientists/

6.     Daily Cannabis News, http://thedailycannabisnews.com/understand-the-risks-and-benefits-of-cannabis-use-in-young-patients/

7.     World Weed Magazine, https://www.weedworldmagazine.org/2021/06/22/scientists-medical-cannabis-may-be-effective-for-epilepsy-patients/

8.     Tucker Cannabis Press http://tuckercannabispress.com/understand-the-risks-and-benefits-of-cannabis-use-in-young-patients/

9.     Cannabis Health News—UK, https://cannabishealthnews.co.uk/2021/06/22/researchers-examine-effects-of-medical-cannabis-on-children/

10.  Cannabise Saude—Brazil, https://www.cannabisesaude.com.br/cannabis-medicinal-tratamento-criancas/

11.  Glocalist—Germany, https://glocalist.press/login/?redirect_to=https%3A%2F%2Fglocalist.press%2Fhebrew-university-israel-understanding-the-impact-of-medical-marijuana-on-children-auswirkung-von-medizinischem-marihuana-auf-kinder%2F

12.  Today UK News, https://todayuknews.com/health/understanding-the-impact-of-medical-marijuana-on-kids-a-meta-analysis/

13.  Israel 365, https://www.israel365news.com/194062/much-more-must-be-learned-to-determine-medical-and-psychological-effects-of-medical-cannabis-on-youngsters-say-hebrew-university-research/

14.  Arutz Sheva, https://www.israelnationalnews.com/News/News.aspx/308459

15.  Jewish Press, https://www.jewishpress.com/news/israel/jerusalem/hebrew-u-reveals-impact-of-medical-marijuana-on-children/2021/06/21/

16.  JWire, https://www.jwire.com.au/medical-cannabis-for-younger-patients/

17.  No Camels, https://nocamels.com/2021/06/medical-cannabis-kids-epilepsy-new-israeli-study/

18.  LatAm Israel—Latin America, https://latamisrael.com/el-impacto-de-la-marihuana-medicinal-en-los-ninos/

19.  Enlace Judio—Mexico, https://www.enlacejudio.com/2021/06/22/estudio-israeli-cannabis-medicinal-podria-ser-benefico-para-pacientes-jovenes-con-epilepsia/

20.  Ashdod Café, https://www.ashdodcafe.com/2021/06/22/israel-le-cannabis-medical-aide-les-enfants-atteints-depilepsie-severe/

21.YNET, https://www.ynet.co.il/health/article/HJGG7Lg2u

 

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For the first time: the ICRS2021 World Cannabis Conference will be held in Israel at the Congress Center at the Nation Buildings in collaboration with the Hebrew University

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The International Association for Cannabinoid Research (ICRS) has decided to hold its annual conference this coming June at the Nation Buildings in Jerusalem, in collaboration with the Hebrew University and the Jerusalem Development Authority. The festive event is expected to attract about 800 researchers, doctors and scientists from around the world to Jerusalem. The ICRS conference is the most important in the world in the field of cannabis research. The conference brings together leading researchers from the international scientific community and presents the latest research in the field of cannabis

 

 

The International Building Center of the Buildings of the Nation Jerusalem - in collaboration with the Multidisciplinary Center for Cannabis Research (MCCR) of the Hebrew University, the Jerusalem Development Authority (JCVB) and the ICRS Association - will host the ICRS2021 International Cannabis Conference for the first time in Israel. The conference of the International Association of Cannabinoid Research (ICRS) is expected to take place in June 2021 in the capital and is expected to attract about 800 researchers, doctors and scientists from around the world.

As of this stage, the conference is expected to take place in front of a large audience of participants in the nation's buildings in Jerusalem, assuming that the corona crisis ends before June. If the Ministry of Health's guidelines do not allow for the physical existence of the conference, and the corona crisis continues, the unique event will be held online through the Nation Buildings' Virtual Congress Center platform.

The ICRS conference is the most important in the world in the field of cannabis research. It brings together leading researchers from the international scientific community and presents the latest and most up-to-date research in the field of cannabis. The conference will include frontal lectures and the presentation of posters covering a wide range of topics related to cannabis science, such as: autoimmune diseases, epilepsy, pain, post-trauma, drug development and medical chemistry, metabolism, obesity, cancer, and more.

The conference will be sponsored by the Multidisciplinary Center for Cannabis Research (MCCR) of the Hebrew University, which is the leading center in Israel for conducting research on cannabinoids, endocannabinoids and medical cannabis.

For the past 50 years, research by the Hebrew University has led the science of cannabis. This year will be marked at the 90th birthday conference of Prof. Rafael Meshulam, a university researcher in his hometown of Jerusalem. Prof. Meshulam, who is considered the "father of cannabinoid research", and his colleagues isolated the active ingredients of the cannabis plant, described their structure and synthesized them. Last December, Prof. Meshulam was awarded the prestigious Harvey Prize for 2020-2019 for discovering the endocannabinoid system and studying its implications for human health.

 

 


The ICRS is a non-profit organization in the United States that has been created as a safe space to discuss cannabis science.

 

 

Prof. Yossi Tam of the Hebrew University School of Pharmacy, who serves as president of the ICRS Association and head of the MCCR, one of the event organizers, noted that "the Board of Trustees of the ICRS Association is pleased to host the 31st Conference of the Jerusalem Association, The most important cannabinoids today are made in Israel. I am confident that hosting this conference at the highest level will be another turning point in Israel's position as a world leader in the research and development of cannabis and cannabinoids. "

Rakefet Eliaz Iluz, VP of Marketing and Business Development at the Nation Buildings in Jerusalem, said: As part of the process, we approached a complex tender, hosted the heads of the association with us in the nation's buildings, presented them with our vision for the conference and I am very happy that the ICRS2021 conference will be held with us in June this year. "

Eliez Iluz added: "We all hope that the conference will be held physically in the buildings of the nation of Jerusalem in the presence of hundreds of distinguished guests from all over the world. - A professional studio and a permanent stage equipped with advanced equipment and a virtual congress center. "

Media publications:

https://m.maariv.co.il/breaking-news/Article-819278?utm_source=whatsapp

https: //finance.walla.co.il/item/3415502? utm_source = whatsup & utm_medium = s ...

http://www.ice.co.il/consumerism/news/article/807419

https://jerusalem.mynet.co.il/health/article/BJbF7KUe00

https://rotter.net/forum/scoops1/681439.shtml

http://www.talniri.co.il/marketnews/article.asp?mp=49&cat=1&id=101367

 

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Many women refuse to have a mammogram because of the use of a metallic marker - new study finds possible solution to problem

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A new Israeli study has succeeded in leading for the first time in the world of medicine to the development of a biodegradable marker in favor of a mammogram. After a marker was developed from natural and familiar materials, an animal experiment was conducted, the results of which were promising - the toxicity of the substance was ruled out, and it disappeared from the animal body within a few months. A scientific paper on the study was published in the journal ACS applied biomaterials. The Hebrew University patented the technology

 

 

 

 

During the mammography examination process, when cancerous tissue is detected, a biopsy of the same tissue is performed, and the tissue is sometimes left for follow-up for several months to make sure that no tumors are developing. To mark the suspicious tissue in favor of the medical treatment, a metal marker about 5 mm is injected into the subject's breast, which remains in the breast for the entire life of the subject. Prof. Zehava Glimidi, head of the mammography service at Rambam Hospital, was troubled by this. Many women refuse to accept the metallic marker that usually remains in a woman's body until her death, so she turned to Prof. Avi Domb, head of the School of Pharmacy at the Hebrew University of Jerusalem, to develop a biodegradable marker that would disappear from the body after the tests and months of medical follow-up.

According to Prof. Domb, "A woman who undergoes a mammogram is forced to remain with a metallic marker on her body for the rest of her life, and often more than one marker if there are several foci suspected of cancer in her body. The fear of those women using the same inexhaustible markers is understandable Was to try and think about how to alleviate the distress of those women, to create markers that are perishable, polymers or organic materials, that might match the imaging systems used to perform a mammogram.By the way, metallic components can move in and out of the body over the years in unwanted ways, so I also understand that it is better not to stay with the same metals in the body for a long time. "

According to the study, which is funded by the Fireplace Innovation Program, a biodegradable marker has been developed for the first time that can be viewed on conventional imaging devices, including MRI, ultrasound, and CT. Prof. Domb and his team at the Hebrew University used approved materials for use in the human body, because the development of a product from new materials requires more approvals before the experiments begin. It was therefore decided to use tiny poles of biodegradable polymers that are commonly used in the medical world that have been implanted in animals and observed for over three months. Polymers have been added to commonly used contrast agents such as barium sulfate and iodixanol. The results of the study were promising and the marker was detected using the three imaging systems, CT, MRI and ultrasound, even three months after the transplant and the marker's depletion process took place over time, until it disappeared.

Examination of the tissues in which the tiny rods were implanted revealed no signs of systemic toxicity in the animals. According to the results, the materials developed could be a potential substitute for metal-based markers, "read an article detailing the scientific experiment, published in the journal ACS applied biomaterials, quoted in the Journal of the American Chemicals Association. . In addition to using mammography, the biodegradable marker can mark tissues that need to be dissected or tissues that need to be monitored for changes.

 

 

 

During the mammography examination process, when cancerous tissue is detected, a biopsy of the same tissue is performed, and the tissue is sometimes left for follow-up for several months to make sure that no tumors are developing. To mark the suspicious tissue in favor of the medical treatment, a metal marker about 5 mm is injected into the subject's breast, which remains in the breast for the entire life of the subject. Prof. Zehava Glimidi, head of the mammography service at Rambam Hospital, was troubled by this. Many women refuse to accept the metallic marker that usually remains in a woman's body until her death, so she turned to Prof. Avi Domb, head of the School of Pharmacy at the Hebrew University of Jerusalem, to develop a biodegradable marker that would disappear from the body after the tests and months of medical follow-up.

According to Prof. Domb, "A woman who undergoes a mammogram is forced to remain with a metallic marker on her body for the rest of her life, and often more than one marker if there are several foci suspected of cancer in her body. The fear of those women using the same inexhaustible markers is understandable Was to try and think about how to alleviate the distress of those women, to create markers that are perishable, polymers or organic materials, that might match the imaging systems used to perform a mammogram.By the way, metallic components can move in and out of the body over the years in unwanted ways, so I also understand that it is better not to stay with the same metals in the body for a long time. "

According to the study, which is funded by the Fireplace Innovation Program, a biodegradable marker has been developed for the first time that can be viewed on conventional imaging devices, including MRI, ultrasound, and CT. Prof. Domb and his team at the Hebrew University used approved materials for use in the human body, because the development of a product from new materials requires more approvals before the experiments begin. It was therefore decided to use tiny poles of biodegradable polymers that are commonly used in the medical world that have been implanted in animals and observed for over three months. Polymers have been added to commonly used contrast agents such as barium sulfate and iodixanol. The results of the study were promising and the marker was detected using the three imaging systems, CT, MRI and ultrasound, even three months after the transplant and the marker's depletion process took place over time, until it disappeared.

Dr. Moran Haim Zeda from the Hebrew University, Prof. Zehava Galmidi from Rambam Medical Campus, Prof. Avraham Niska from Tel Aviv University, and Dr. Michal Schlesinger from the Technion also participated in this study.

The Hebrew University of Jerusalem has registered a patent for the latest technology and hopes to develop the product in the future with the help of investors. Until then, after performing the successful animal experiment, Prof. Domb is looking for a factor that would be interested in initially developing the product for the benefit of the clinical trial phase in humans, to test whether the product is able to fulfill its function and purpose in human tissues as well. "Hopefully there is a body that will agree to fund this and then the path to product development for public use will be shortened," the researcher clarifies.

Breast cancer is the most common malignant disease in Israel and in the Western world in general. About 5,000 women are diagnosed with breast cancer in Israel each year. As the disease is diagnosed in the early stages, the chances of cure increase to about 90%, among other things by performing a mammogram on time. According to the Association for the War on Cancer, it seems that the number of women recovering from breast cancer is steadily increasing thanks to early detection and thanks to improved treatment methods and increased widespread awareness in the country.

To read the full article:

https://pubs.acs.org/doi/10.1021/acsabm.0c00655

 

Media publications:

Channel 7 - https://www.inn.co.il/news/460096

Madnews: https://mednews.co.il/mammography-examination-with-a-biodegradable-marker/

Hayadan: https: //www.hayadan.org.il/%D7%A0%D7%A9%D7%99%D7%9D-%D7%A8%D7%91%D7%95%D ...

Mortek: https://news.mortech.co.il/2020/12/blog-post_11.html

Rinunim - https://www.rinunim.co.il/Article.php?CatID=&Page=&ArticleID=49090

Three who know, Kan news - https://www.kan.org.il/Podcast/item.aspx?pid=19108

https://www.israel365news.com/161883/jerusalem-researchers-develop-techn ..

 

 

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