On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research

Citation:

Constantin Itin, Abraham J. Domb, and Amnon Hoffman. 2021. “On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research.” Journal of Pharmaceutical Sciences, 110, 4, Pp. 1863–1864.

Abstract:

Contrary to human, porcine mucosa of the inner side of the lip is parakeratinized. Thus, although desirable due to its large surface area, it does not closely resemble human buccal mucosa to be considered a suitable model for systemic drug delivery research. Nevertheless, it can be utilized for comparative screening of topical or systemic delivery of bioactive agents, mostly lipophilic such as cannabinoids.