Citation:
D Khattib, Ishan, M, Karmakar, S, Kostrhunova, H, Brabec, V, and Gibson, D. 2020. “Oxidation Of Cis-Diamminediacetato Pt(Ii) With Hydrogen Peroxide Can Give Rise To Two Isomeric Pt(Iv) Products.”. Chemistry (Weinheim An Der Bergstrasse, Germany), 26, 43, Pp. 9475–9480. doi:10.1002/chem.202001472.
Abstract:
The oxidation of cis-[Pt(NH(3) )(2) (OAc)(2) ] with H(2) O(2) yields a mixture of two isomers: ctc-[Pt(NH(3) )(2) (OH)(2) (OAc)(2) ] and ctc-[Pt(NH(3) )(2) (OH)(OAc)(OH)(OAc)]. Following modification with 4-phenylbutyric (PhB) anhydride, two isomers were separated and characterized; the symmetric ctc-[Pt(NH(3) )(2) (PhB)(2) (OAc)(2) ] (1) and the nonsymmetric ctc-[Pt(NH(3) )(2) (PhB)(OAc)(PhB)(OAc)] (2). They differ in their log P values and despite having similar cellular uptake and similar DNA platination levels, the symmetric ctc-[Pt(NH(3) )(2) (OH)(2) (OAc)(2) ] is more than 4-fold more potent than the nonsymmetric isomer in a panel of 4 cancer cell lines.