Cyclopentane FIT-PNAs: Bright RNA sensors


Odelia Tepper, Hongchao Zheng, Daniel H. Appella, and Eylon Yavin. 2021. “Cyclopentane FIT-PNAs: Bright RNA sensors.” Chemical Communications, 57, 4, Pp. 540–543.


Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).