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Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy. | School of Pharmacy

Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy.

Citation:

Sarah Israel, Elinav, Hila , Elazary, Ram , Porat, Daniel , Gibori, Roni , Dahan, Arik , Azran, Carmil , and Horwitz, Ehud . 2020. “Case Report Of Increased Exposure To Antiretrovirals Following Sleeve Gastrectomy.”. Antimicrobial Agents And Chemotherapy, 64, 4. doi:10.1128/AAC.02453-19.

Abstract:

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ∼12-fold. Several mechanistic explanations for these findings are discussed.