The School of Pharmacy at the Hebrew University, one of the world leaders in pharmacist training and basic research in the pharmaceutical sciences, was established in 1953.
The school prepares its graduates to practice the pharmacy profession, provides them with a scientific and professional foundation, and offers higher studies in pharmacology, medicinal chemistry and pharmacy sciences (M.Sc. and Ph.D.), as well as doctoral studies in clinical pharmacy (Pharm.D.).
Graduates of the school are integrated in community pharmacy (community pharmacies, private and institutional), clinical pharmacy (hospitals and health funds), the pharmaceutical industry, the biological, chemical and biotechnology industries, the pharmacy administration and science and research institutions in Israel and abroad.
The school conducts extensive scientific research in the fields of pharmaceutical sciences and life sciences, and dozens of articles are published each year in the leading press in the world of science.
The School of Pharmacy is part of the Faculty of Medicine, located on the Ein Kerem campus of the Hebrew University and works closely with physicians and researchers from Hadassah Hospital.

## Weekly Seminar - Prof. Amiram Goldblum- Why Multitargeting? Why in Silico ?

Thu, 09/06/202212:00-13:00
Location:
Hall .A. School of Pharmacy 1st floor

## Weekly Seminar - Bruria Hirsh Raccah , Pharm.D PhD, - Pharmacoepidemiology Research for Decision Making: cardiovascular outcomes of Antithrombotic drugs , Statins and medical cannabinoids in specific population

Thu, 02/06/202212:00-13:00
Location:
Hall .A. School of Pharmacy 1st floor

## Weekly Seminar - Dr. Amichai Perlman - Anticoagulant drug interactions and the potential for synergistic interactions between clinical pharmacology and data science

Thu, 26/05/202212:00-13:00
Location:
Hall .A. School of Pharmacy 1st floor
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## RSC Medicinal Chemistry poster prize for Talya Hanna Avraham

Congratulations to Talya Hanna Avraham from Blum lab for winning the RSC Medicinal Chemistry poster prize at the 18th annual meeting of the Medicinal Chemistry Section of the Israel Chemical Society 2022

## Honorary Fellowship of the Royal College of Physicians Award for Prof. Francesca Levi-Schaffer

Congratulations to Prof. Francesca Levi-Schaffer for the Honorary Fellowship of the Royal College of Physicians Award

## A Novel Sanitizing Technology Invented At The School Of Pharmacy Has Generated A Range Of Products Now In Use In South America

Prof. Touitou has developed a novel broad spectrum anti-viral and anti-microbial sanitizing technology based on a new concept of action. The mode of action is based on a synergistic combination of ingredients providing high antiviral and antimicrobial activities, yet being non-irritating, quick drying, non-sticky and not drying the skin.

It prevents the spread of disease by effectively disinfecting hands and surfaces against bacteria, enveloped and non-enveloped viruses. The antimicrobial and antiviral spectrum of the active ingredients include biocidal performance against gram-positive bacteria, gram-negative bacteria, mycobacteria, fungi, enveloped viruses and non-enveloped viruses.

The novel compositions, tested in leading in FDA and EPA certified GLP labs, exhibited effective anti-viral, anti-microbial and/or anti-fungal activity.

Prof. Elka Touitou Head of Innovative Dermal Transdermal &Transmucosal Delivery Group, Institute of Drug Research School of Pharmacy, Faculty of Medicine The Hebrew University of Jerusalem

The figures above depict the synergistic antiviral activity of formulations tested for their antiviral activity against Vaccinia virus after 30 & 60 seconds exposure respectively as compared to conventional formulations

The active ingredients in the products of the novel technology are regarded as safe (GRAS) by the US FDA and are listed in the FDA's EAFUS database. The compositions of the invention can be used in mouthwashes, oral care, hand sanitizing and food Surfaces sanitizers. They can also be used for sanitizing and/or disinfecting surfaces. The new sanitizers are pleasant and non–tacky on the skin.

The IP has been licensed and a range of products are now in use in South America

The new products answer the unmet medical needs by providing innovative and highly effective sanitizing solution to prevent the spread of bacteria and viruses.

## Dr. Haitham Amal in The De Marker's 40 Most Promising Young People Under 40!

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## Recent Publications

Autism spectrum disorder (ASD) is a neurodevelopmental disorder manifested in repetitive behavior, abnormalities in social interactions, and communication. The pathogenesis of this disorder is not clear, and no effective treatment is currently available. Protein S-nitrosylation (SNO), the nitric oxide (NO)-mediated posttranslational modification, targets key proteins implicated in synaptic and neuronal functions. Previously, we have shown that NO and SNO are involved in the ASD mouse model based on the Shank3 mutation. The energy supply to the brain mostly relies on oxidative phosphorylation in the mitochondria. Recent studies show that mitochondrial dysfunction and oxidative stress are involved in ASD pathology. In this work, we performed SNO prote-omics analysis of cortical tissues of the Shank3 mouse model of ASD with the focus on mitochondrial proteins and processes. The study was based on the SNOTRAP technology followed by systems biology analysis. This work revealed that 63 mitochondrial proteins were S-nitrosylated and that several mitochondria-related processes, including those associated with oxidative phosphorylation, oxidative stress, and apoptosis, were enriched. This study implies that aberrant SNO signaling induced by the Shank3 mutation can target a wide range of mitochondria-related proteins and processes that may contribute to the ASD pathology. It is the first study to investigate the role of NO-dependent mitochondrial functions in ASD.
Nethanel Friedman, Arie Dagan, Jhonathan Elia, Sharon Merims, and Ofra Benny. 2021. “Physical properties of gold nanoparticles affect skin penetration via hair follicles.” Nanomedicine: Nanotechnology, Biology, and Medicine, 36. Abstract
Drug penetration through the skin is significant for both transdermal and dermal delivery. One mechanism that has attracted attention over the last two decades is the transport pathway of nanoparticles via hair follicle, through the epidermis, directly to the pilosebaceous unit and blood vessels. Studies demonstrate that particle size is an important factor for drug penetration. However, in order to gain more information for the purpose of improving this mode of drug delivery, a thorough understanding of the optimal physical particle properties is needed. In this study, we fabricated fluorescently labeled gold nanoparticles (GNP) with a tight control over the size and shape. The effect of the particles' physical parameters on follicular penetration was evaluated histologically. We used horizontal human skin sections and found that the optimal size for polymeric particles is 0.25 $μ$m. In addition, shape penetration experiments revealed gold nanostars' superiority over spherical particles. Our findings suggest the importance of the particles' physical properties in the design of nanocarriers delivered to the pilosebaceous unit.
Yoel Goldstein, Sarah Spitz, Keren Turjeman, Florian Selinger, Yechezkel Barenholz, Peter Ertl, Ofra Benny, and Danny Bavli. 2021. “Breaking the third wall: Implementing 3d-printing technics to expand the complexity and abilities of multi-organ-on-a-chip devices.” Micromachines, 12, 6. Abstract
The understanding that systemic context and tissue crosstalk are essential keys for bridg-ing the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices. However, many of the proposed devices have failed to implement the means to allow for conditions tailored to each organ individually, a crucial aspect in cell functionality. Here, we present two 3D-print-based fabrication methods for a generic multi-organ-on-a-chip device: One with a PDMS microfluidic core unit and one based on 3D-printed units. The device was designed for culturing different tissues in separate compartments by integrating individual pairs of inlets and outlets, thus enabling tissue-specific perfusion rates that facilitate the generation of individual tissue-adapted perfusion profiles. The device allowed tissue crosstalk using microchannel configuration and permeable membranes used as barriers between individual cell culture compartments. Computational fluid dynamics (CFD) simulation confirmed the capability to generate significant differences in shear stress between the two individual culture compartments, each with a selective shear force. In addition, we provide preliminary findings that indicate the feasibility for biological compatibility for cell culture and long-term incubation in 3D-printed wells. Finally, we offer a cost-effective, accessible protocol enabling the design and fabrication of advanced multi-organ-on-a-chip devices.
Lior Minkowicz, Arie Dagan, Vladimir Uvarov, and Ofra Benny. 2021. “Controlling calcium carbonate particle morphology, size, and molecular order using silicate.” Materials, 14, 13. Abstract
Calcium carbonate (CaCO3) is one of the most abundant substances on earth and has a large array of industrial applications. Considerable research has been conducted in an effort to synthesize calcium carbonate microparticles with controllable and specific morphologies and sizes. CaCO3 produced by a precipitation reaction of calcium nitrate and sodium carbonate solution was found to have high polymorphism and batch to batch variability. In this study, we investigated the polymorphism of the precipitated material and analyzed the chemical composition, particle morphology, and crystalline state revealing that the presence of silicon atoms in the precipitant is a key factor effecting particle shape and crystal state. An elemental analysis of single particles within a polymorphic sample, using energy‐dispersive X‐ray spectroscopy (EDS) conjugated microscopy, showed that only spherical particles, but not irregular shaped one, contained traces of silicon atoms. In agreement, silicon‐containing additives lead to homogenous, amorphous nanosphere particles, verified by X‐ray powder diffraction (XRD). Our findings provide important insights into the mechanism of calcium carbonate synthesis, as well as introducing a method to control the precipitants at the micro‐scale for many diverse applications.
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