The School of Pharmacy at the Hebrew University, one of the world leaders in pharmacist training and basic research in the pharmaceutical sciences, was established in 1953.
The school prepares its graduates to practice the pharmacy profession, provides them with a scientific and professional foundation, and offers higher studies in pharmacology, medicinal chemistry and pharmacy sciences (M.Sc. and Ph.D.), as well as doctoral studies in clinical pharmacy (Pharm.D.).
Graduates of the school are integrated in community pharmacy (community pharmacies, private and institutional), clinical pharmacy (hospitals and health funds), the pharmaceutical industry, the biological, chemical and biotechnology industries, the pharmacy administration and science and research institutions in Israel and abroad.
The school conducts extensive scientific research in the fields of pharmaceutical sciences and life sciences, and dozens of articles are published each year in the leading press in the world of science.
The School of Pharmacy is part of the Faculty of Medicine, located on the Ein Kerem campus of the Hebrew University and works closely with physicians and researchers from Hadassah Hospital.

## Weekly Seminar - RXR and ROR as targets for natural products and structural analogs

Thu, 01/12/202212:00-13:00
Location:
Hall .A. School of Pharmacy 1st floor

## Weekly Seminar - AI-Guided Optical Sensors for The Early Detection of Gynecologic Cancers

Thu, 10/11/202212:00-13:00
Location:
Hall .A. School of Pharmacy 1st floor

## Weekly Seminar - Prof. Klaus Yant Batsheva de Rothschild Fellow 2022 Chair of Materials Science

Wed, 02/11/202212:00-13:00
Location:
Hall .A. School of Pharmacy 1st floor
All events >>

## Grant from the Israel Ministry of Science and Technology

Significant Achievement for our School! 8 Researchers were awarded the highly competitive Science Upfront grant from the Israel Ministry of Science and Technology! Notably 4 of the awardees are young PIs that join our institute in the past 3 years! Congratulations to Boaz Tirosh, Eylon Yavin, Ofra Benny, Reuven Reich, Raphael Benhamou, Gali Umschweif, Katy Margulis and Tawfeeq Shekh Ahmad!

## RSC Medicinal Chemistry poster prize for Talya Hanna Avraham

Congratulations to Talya Hanna Avraham from Blum lab for winning the RSC Medicinal Chemistry poster prize at the 18th annual meeting of the Medicinal Chemistry Section of the Israel Chemical Society 2022

## Honorary Fellowship of the Royal College of Physicians Award for Prof. Francesca Levi-Schaffer

Congratulations to Prof. Francesca Levi-Schaffer for the Honorary Fellowship of the Royal College of Physicians Award

## A Novel Sanitizing Technology Invented At The School Of Pharmacy Has Generated A Range Of Products Now In Use In South America

Prof. Touitou has developed a novel broad spectrum anti-viral and anti-microbial sanitizing technology based on a new concept of action. The mode of action is based on a synergistic combination of ingredients providing high antiviral and antimicrobial activities, yet being non-irritating, quick drying, non-sticky and not drying the skin.

It prevents the spread of disease by effectively disinfecting hands and surfaces against bacteria, enveloped and non-enveloped viruses. The antimicrobial and antiviral spectrum of the active ingredients include biocidal performance against gram-positive bacteria, gram-negative bacteria, mycobacteria, fungi, enveloped viruses and non-enveloped viruses.

The novel compositions, tested in leading in FDA and EPA certified GLP labs, exhibited effective anti-viral, anti-microbial and/or anti-fungal activity.

Prof. Elka Touitou Head of Innovative Dermal Transdermal &Transmucosal Delivery Group, Institute of Drug Research School of Pharmacy, Faculty of Medicine The Hebrew University of Jerusalem

The figures above depict the synergistic antiviral activity of formulations tested for their antiviral activity against Vaccinia virus after 30 & 60 seconds exposure respectively as compared to conventional formulations

The active ingredients in the products of the novel technology are regarded as safe (GRAS) by the US FDA and are listed in the FDA's EAFUS database. The compositions of the invention can be used in mouthwashes, oral care, hand sanitizing and food Surfaces sanitizers. They can also be used for sanitizing and/or disinfecting surfaces. The new sanitizers are pleasant and non–tacky on the skin.

The IP has been licensed and a range of products are now in use in South America

The new products answer the unmet medical needs by providing innovative and highly effective sanitizing solution to prevent the spread of bacteria and viruses.

Gout is an inflammatory disease triggered by deposition of monosodium urate (MSU) crystals in the joints, resulting in high neutrophil influx and pain. Here, we studied the role of the inhibitory receptor CD300a in the resolution process in a murine model of gout. We found increased CD300a expression on neutrophils emigrated to the joint. When compared to WT mice, CD300a−/− mice had persistent neutrophil influx till 24 hr after MSU injection. This was associated with increased concentration of IL-1$\beta$ and greater tissue damage in the joints of CD300a−/− mice. There was an increase in the percentage of apoptotic neutrophils in the synovial lavage of WT mice, as compared to CD300a−/− mice. This difference was reflected in the decline of efferocytic events in the synovial cavity of CD300a−/− mice 24 hr after MSU injection. A CD300a agonistic antibody was shown, for the first time, to increase apoptosis of human neutrophils, and this was associated with cleavage of caspase-8. In conclusion, our results reveal an important role of CD300a in the control of leucocyte infiltration, IL-1$\beta$ production and caspase-8 cleavage in neutrophils, contributing to the resolution of inflammation triggered by MSU injection.
The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). 8-Br (10 $μ$M) was administered to Langendorff-perfused rat hearts for 5 min either before or at the end of 30 min regional ischaemia. Ca2+-induced mitochondria swelling (a measure of MPTP opening) and binding of hexokinase II (HKII) to mitochondria were assessed following the drug treatment at preischaemia. Haemodynamic function and ventricular arrhythmias were monitored during ischaemia and 2 h reperfusion. Infarct size was evaluated at the end of reperfusion. 8-Br administered before ischaemia attenuated ventricular arrhythmias, improved haemodynamic function, and reduced infarct size during ischaemia/reperfusion. Application of 8-Br at the end of ischaemia protected the heart during reperfusion. 8-Br promoted binding of HKII to the mitochondria and reduced Ca2+-induced mitochondria swelling. Thus, 8-Br protects the heart when administered before regional ischaemia or at the beginning of reperfusion. This effect is associated with inhibition of MPTP via binding of HKII to mitochondria, which may underlie the protective mechanism.
Drug penetration through the skin is significant for both transdermal and dermal delivery. One mechanism that has attracted attention over the last two decades is the transport pathway of nanoparticles via hair follicle, through the epidermis, directly to the pilosebaceous unit and blood vessels. Studies demonstrate that particle size is an important factor for drug penetration. However, in order to gain more information for the purpose of improving this mode of drug delivery, a thorough understanding of the optimal physical particle properties is needed. In this study, we fabricated fluorescently labeled gold nanoparticles (GNP) with a tight control over the size and shape. The effect of the particles' physical parameters on follicular penetration was evaluated histologically. We used horizontal human skin sections and found that the optimal size for polymeric particles is 0.25 $μ$m. In addition, shape penetration experiments revealed gold nanostars' superiority over spherical particles. Our findings suggest the importance of the particles' physical properties in the design of nanocarriers delivered to the pilosebaceous unit.